Cancer BiologyBrainPeer-reviewed
De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma
J. M. Shireman, F. Atashi, G. Lee…·A. U. Ahmed
This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.
DOI 10.1093/brain/awab020