C. Horbinski

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

This paper introduces Deep3P, a three-photon microscopy and AI analysis method that enables deep intravital imaging of glioblastoma in mouse brains, revealing new insights into tumor invasion routes and white matter disruption.

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

SerpinB3 drives cancer stem cell survival in glioblastoma

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.

The efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma

This study evaluates the efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant gliomas, finding no significant effect on tumor growth or survival.

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

The paper identifies PSMB3 as a contributor to gliomagenesis through proteasome-dependent and independent mechanisms using a CRISPR-Cas9 screen in GBM.

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.

Neural Stem Cells Secreting Bispecific T Cell Engager to Induce Selective Anti-Glioma Activity

This study develops neural stem cells secreting a bispecific T cell engager (BiTE) to target glioblastoma, showing survival benefits in mice with IL13R2+ tumors.

The ketogenic diet is not effective in preclinical models of IDH1 wild-type and IDH1 mutant glioma

This study shows that a ketogenic diet does not slow the growth of IDH1 wild-type or mutant gliomas in preclinical models.

MSCs Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

This study shows that mesenchymal stem cells can deliver oncolytic virotherapy to DIPG tumors, significantly improving survival when combined with radiotherapy in preclinical models.

Integrin α6β4 is downregulated in mutant IDH1 oligodendrogliomas, promotes glioma growth, and associates with a worse outcome in glioma patients

This study shows integrin α6β4 is downregulated in IDH1 mutant oligodendrogliomas, promotes glioma growth, and is linked to worse patient outcomes.

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.