Author

J. C. David

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. U. Ahmed· 1 shared B. Jacobson· 1 shared B. S. Wilson· 1 shared C. Horbinski· 1 shared C. Park· 1 shared D. A. Rinaldi· 1 shared D. S. Lidke· 1 shared E. A. Burns· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. U. Ahmed

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Author profile →

2 papers

Recent·Most cited

Antigen properties shape organization of FcεRI aggregates to tune mast cell signaling

D. A. Rinaldi, W. K. Kanagy, R. M. Grattan, J. C. David, H. C. Kaye, E. A. Burns, S. R. Lucero, M. P. Perez, M. J. Wester, L. Tapia, B. Jacobson, K. A. Lidke, B. S. Wilson, D. S. Lidke

This study shows that antigen properties like valency and epitope spacing shape FcεRI aggregate structure, influencing mast cell signaling outcomes.

bioRxiv · Aug 4, 2023 · PreprintBiophysics

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

J. M. Shireman, F. Atashi, G. Lee, E. Ali, M. Saathoff, C. Park, S. Baiswala, J. Miska, M. Lesniak, J. C. David, R. Stupp, P. Kumthekar, C. Horbinski, I. Ben-Sahar, A. U. Ahmed

This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.

Brain · Apr 14, 2021Peer-reviewedCancer Biology