Author

I. Bieche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. Vacher· 3 shared E. Jeannot· 2 shared L. Cabel· 2 shared A. Boutillon· 1 shared A. De Reynies· 1 shared A. I. Fokin· 1 shared A. Kamoun· 1 shared A. M. Gautreau· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

S. Vacher

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Author profile →

5 papers

Recent·Most cited

Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell Migration

A. I. Fokin, A. Boutillon, J. James, L. Courtois, S. Vacher, G. Simanov, Y. Wang, A. Polesskaya, I. Bieche, N. B. David, A. M. Gautreau

The paper shows that inactivating three negative regulators of cortical branched actin enhances migration persistence in human and zebrafish cells, with vimentin down-regulation contributing to the stable maintenance of this phenotype.

bioRxiv · May 13, 2023Cell Biology

Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies.

H. Lang, C. Beraud, L. Cabel, M. Lassalle, J. Fontugne, C. Krucker, F. Dufour, C. S. Groeneveld, V. Dixon, X. Meng, A. Kamoun, E. Chapeaublanc, A. De Reynies, X. Game, P. Rischmann, , T. Massfelder

The paper develops patient-derived xenografts (PDXs) for bladder and ureteral cancers, identifies molecular subtypes, and shows that combined FGFR/EGFR inhibition is more effective than single-agent therapy for FGFR3-mutant tumors.

Frontiers in Oncology · Aug 11, 2022Peer-reviewedCancer Biology

Upregulated-flotillins and sphingosine kinase 2 derail vesicular trafic to stabilize AXL and promote epithelial-mesenchymal transition

M. Genest, F. Comunale, D. Planchon, P. Govindin, S. Vacher, I. Bieche, B. Robert, H. Malhotra, A. Schoenit, L. Tashireva, C. Gauthier-Rouviere, S. Bodin

The paper shows that flotillin overexpression and sphingosine kinase 2 promote AXL stabilization via altered vesicular trafficking, enhancing EMT in mammary epithelial cells.

bioRxiv · May 12, 2020Cell Biology

MMP2 As An Independent Prognostic Stratifier In Oral Cavity Cancers

C. Hoffmann, S. Vacher, P. Sirven, C. Lecerf, L. Massenet, A. Moreira, A. Surun, A. Schnitzler, J. Klijanienko, O. Mariani, E. Jeannot, N. Badois, M. Lesnik, O. Choussy, C. Le Tourneau, , V. Soumelis

The paper identifies MMP2 as an independent prognostic biomarker for oral cavity cancers, associated with poor disease-specific survival.

bioRxiv · Aug 2, 2019Cancer Biology

A single droplet digital PCR for ESR1 activating mutations detection in plasma

E. Jeannot, L. Darrigues, M. Michel, M.-H. Stern, J.-Y. Pierga, A. Rampanou, S. Melaabi, C. Benoist, I. Bieche, A. Vincent-Salomon, R. El Ayachy, A. Noret, N. Epaillard, L. Cabel, F.-C. Bidard, C. Proudhon

This paper develops a multiplex droplet digital PCR assay for detecting ESR1 activating mutations in plasma, showing high sensitivity and concordance with NGS data.

bioRxiv · Jan 8, 2019Cancer Biology