J. James

Co-circulation of distinct high pathogenicity avian influenza virus (HPAIV) subtypes in a mass mortality event in wild seabirds and co-location with dead seals

The paper reports the co-circulation of H5N1 and H5N5 HPAIV subtypes in a mass mortality event involving seabirds and seals in Great Britain, with the first recorded instance of two subtypes co-occurring in the same avian population and the first H5N5 detection in mammals in GB.

The Haemagglutinin Genes of the UK Clade 2.3.4.4b H5N1 Avian Influenza Viruses from 2020 to 2022 Retain Strong Avian Phenotype

This study evaluates HA functionality of UK H5N1 avian influenza viruses from 2020-2022, finding they retain strong avian phenotype with low zoonotic threat.

Validation of Optimized Methods for Avian Influenza Virus Isolation in Specific Pathogen-Free Embryonated Fowl Eggs

The paper validates optimized methods for avian influenza virus isolation in specific pathogen-free embryonated fowl eggs, reducing isolation time while maintaining sensitivity.

Rapid mortality in captive bush dogs (Speothos venaticus) caused by influenza A of avian origin (H5N1) at a wildlife collection in the United Kingdom

This study reports an unusual mortality event in captive bush dogs caused by avian-origin H5N1 influenza A virus.

Evaluating the epizootic and zoonotic threat of an H7N9 low pathogenicity avian influenza virus (LPAIV) variant associated with enhanced pathogenicity in turkeys

This study evaluates the increased pathogenicity and zoonotic potential of an H7N9 LPAIV variant in turkeys, showing enhanced virulence and transmission risks.

Optimisation strategies for directed evolution without sequencing

This paper develops selection strategies for directed evolution without sequencing, showing they can increase the probability of finding the global fitness peak by up to 7.5 fold.

Learning-Based Estimation of Fitness Landscape Ruggedness for Directed Evolution

This paper introduces a learning-based method to estimate fitness landscape ruggedness during directed evolution using population average performance data, improving experimental outcomes.

Detection and spread of high pathogenicity avian influenza virus H5N1 in the Antarctic Region

This study detects H5N1 HPAIV in Antarctic and sub-Antarctic regions, identifies affected species, and traces the virus's origin and potential spread.

Vinculin-Arp2/3 Interaction Inhibits Branched Actin Assembly to Control Cell Migration and Cell Cycle Progression

This study shows that vinculin's interaction with Arp2/3 inhibits branched actin assembly, affecting cell migration and cell cycle progression in mammary epithelial cells.

Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell Migration

The paper shows that inactivating three negative regulators of cortical branched actin enhances migration persistence in human and zebrafish cells, with vimentin down-regulation contributing to the stable maintenance of this phenotype.

Clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus (HPAIV) from the 2021/22 epizootic is highly duck adapted and poorly adapted to chickens

This study investigates the virulence and transmission of H5N1 HPAIV in ducks and chickens, finding it highly infectious in ducks but poorly adapted to chickens.

High pathogenicity avian influenza (H5N1) in Northern Gannets: Global spread, clinical signs, and demographic consequences

This study tracks the global spread of HPAI H5N1 in Northern Gannets, documenting high mortality rates and demographic impacts across multiple colonies.

The role of airborne particles in the epidemiology of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus in commercial poultry production units

The paper investigates airborne transmission of clade 2.3.4.4b H5N1 HPAIV in poultry units, finding that infectious virus can travel short distances but not between premises, suggesting biosecurity measures are more critical.

Differential retention of Pfam domains creates long-term evolutionary trends

The paper shows that differential retention of protein domains with specific structural properties drives long-term evolutionary trends in Pfam domains.

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

This study shows that internal gene segments from different H9N2 lineages affect the replication and transmission fitness of H7N9 avian influenza viruses in chickens and their zoonotic potential.

Distribution and frequency of salivary gland tumours: an international multicenter study

This study analyzes global salivary gland tumor data from 15 centers to provide updated epidemiological insights on incidence, demographics, and tumor types.

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

This study shows that redox regulation of PTPN22 via cysteine 129 affects T cell-dependent autoimmune inflammation severity in mice.

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

Mitochondrial DNA Sequence Diversity in Mammals: a Correlation Between the Effective and Census Population Sizes

The paper examines mitochondrial DNA diversity in mammals, finding correlations between diversity, range size, and metabolic rate, but not census population size.

Insights from Comparison of the Renal and Skin Single Cell Transcriptomes in Lupus Nephritis

This study uses scRNA-seq to analyze renal and skin biopsies from lupus nephritis patients, identifying IFN signatures and fibrotic pathways associated with disease heterogeneity and non-response.

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

Nearly Neutral Evolution Across the Drosophila melanogaster Genome

The paper examines the relationship between effective population size and the proportion of neutral mutations in Drosophila melanogaster using polymorphism data from North American and African lines.

Simultaneous detection of invasive signal crayfish, endangered white-clawed crayfish and the crayfish plague pathogen using environmental DNA

The paper develops an eDNA HRM method to detect invasive and native crayfish species and their pathogen, providing rapid and sensitive monitoring for conservation.

Intraocular injection of ES cell-derived neural progenitors improve visual function in retinal ganglion cell-depleted mouse models

Transplantation of ES cell-derived neural progenitors improves visual acuity in RGC-depleted mice but not in glaucoma models with high IOP.