Author

H. Lang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

H. Zheng· 2 shared V. Lindner· 2 shared X. Hu· 2 shared A. A. Iwanowicz· 1 shared A. De Reynies· 1 shared A. Helleux· 1 shared A. Kamoun· 1 shared A. R. Haller· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

H. Zheng

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Dihydromyricetin promotes GLP-1 secretion to improve insulin resistance via "gut microbiota-CDCA"

L. Yi, L. p. fei, Y. Zhang, H. Lang, P. Hou, Y. Yao, R. Zhang, X. Wang, Q. Zhang, M. Mi

This study shows that dihydromyricetin improves insulin resistance by enhancing GLP-1 secretion through the gut microbiota-CDCA pathway in HFD-induced mice.

bioRxiv · May 28, 2024 · PreprintPharmacology & Toxicology

Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees

H. Lang, H. Wang, H. Wang, X. Xie, X. Hu, X. Zhang, H. Zheng

The paper shows engineered symbiotic bacteria can inhibit microsporidia infection in honeybees by delivering RNAi targeting the parasite's redox system.

bioRxiv · Jan 13, 2023 · PreprintMicrobiology

Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies.

H. Lang, C. Beraud, L. Cabel, M. Lassalle, J. Fontugne, C. Krucker, F. Dufour, C. S. Groeneveld, V. Dixon, X. Meng, A. Kamoun, E. Chapeaublanc, A. De Reynies, X. Game, P. Rischmann, , T. Massfelder

The paper develops patient-derived xenografts (PDXs) for bladder and ureteral cancers, identifies molecular subtypes, and shows that combined FGFR/EGFR inhibition is more effective than single-agent therapy for FGFR3-mutant tumors.

Frontiers in Oncology · Aug 11, 2022Peer-reviewedCancer Biology

The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells in vitro.

N. Fatima, Y. Shen, K. Crassini, E. Iwanowicz, H. Lang, D. Karanewsky, R. Christopherson, S. Mulligan, G. Best

This study shows TR-57 is effective as a single agent and in combination with venetoclax against CLL cells in vitro, regardless of TP53 aberrations.

bioRxiv · Mar 7, 2022Cancer Biology

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn, K. Drizyte-Miller, E. Leung, Y. E. Greer, P. R. Graves, A. A. Iwanowicz, H. Ashamalla, E. Holmuhamedov, H. Lang, D. S. Karanewsky, C. J. Der, W. A. Houry, S. Lipkowitz, , L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

bioRxiv · Feb 14, 2022Pharmacology & Toxicology

Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilities.

B. H. Vokshi, G. Davidson, A. Helleux, M. Rippinger, A. R. Haller, J. Gantzer, P. Baltzinger, J. Thouvenin, R. Bouarich, V. Manriquez, S. Zaidi, P. Msaouel, X. Su, H. Lang, T. Tricard, , G. G. Malouf

This study uses single-cell and multi-region sequencing to define RMC transformation, identify cell states, and uncover therapeutic vulnerabilities through transcriptional changes and microenvironment interactions.

bioRxiv · Sep 29, 2021 · PreprintCancer Biology

Honeybee genetics shape the strain-level structure of gut microbiota in social transmission

J. Wu, H. Lang, X. Mu, Z. Zhang, Q. Su, X. Hu, H. Zheng

This study shows that honeybee genetics influence gut microbiota composition and strain-level diversity through social transmission, revealing a gut-brain connection.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology