Author

I. Cestari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

T. Sternlieb· 3 shared M. Loock· 2 shared A. Brito Lira· 1 shared A. G. Madrigal· 1 shared A. Jardim· 1 shared A. Kaushansky· 1 shared A. M. Brokaw· 1 shared A. N. Michi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

T. Sternlieb

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

A. O. Touray, R. Rajesh, T. Isebe, T. Sternlieb, M. Loock, O. Kutova, I. Cestari

This study identifies a phosphoinositide signaling system that regulates VSG gene switching in trypanosomes by modulating RAP1's DNA binding activity.

bioRxiv · May 11, 2023Microbiology

The pharmacopeia of helminth-derived metabolites driving tolerance in dendritic cells

A. N. Michi, N. L. Malacco, J. A. Sandoval, E. Siciliani, A. G. Madrigal, T. Sternlieb, G. Fontes, I. L. King, I. Cestari, A. Jardim, M. M. Stevenson, T. Hunter, F. Lopes

The paper identifies helminth-derived metabolites that reprogram dendritic cells to a tolerogenic phenotype, reducing intestinal inflammation in mice.

bioRxiv · Jan 26, 2023 · PreprintImmunology

Genome-wide libraries for protozoan pathogens drug target screening using yeast surface display

R. Heslop, M. Gao, A. Brito Lira, T. Sternlieb, M. Loock, S. R. Sanghi, I. Cestari

The paper develops a method to construct genome-wide libraries for yeast surface display and identifies drug targets in protozoan pathogens using a fitness screen.

bioRxiv · Nov 17, 2022Microbiology

Plasmodium secretion induces hepatocyte lysosome exocytosis and promotes parasite entry

K. Vijayan, I. Cestari, F. D. Mast, E. K. K. Glennon, S. M. McDermott, H. S. Kain, A. M. Brokaw, J. D. Aitchison, K. Stuart, A. Kaushansky

This study shows that Plasmodium sporozoites induce hepatocyte lysosome exocytosis through secreted factors, facilitating parasite entry and highlighting parallels with Trypanosoma cruzi infection.

bioRxiv · Apr 25, 2019Cell Biology