Author

J. D. Aitchison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 2 Microbiology· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

F. D. Mast· 6 shared A. Kaushansky· 3 shared M. L. Neal· 3 shared S. M. McDermott· 3 shared H. S. Kain· 2 shared J. Carnes· 2 shared J. P. Olivier· 2 shared K. D. Stuart· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersCell Biology

F. D. Mast

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

D. A. Oyong, F. J. Duffy, M. L. Neal, Y. Du, J. Carnes, K. V. Schwedhelm, N. Hertoghs, S.-H. Jun, H. Miller, J. D. Aitchison, S. C. De Rosa, E. W. Newell, M. J. McElrath, S. M. McDermott, K. D. Stuart

The paper identifies distinct immune responses associated with vaccination status and protection outcomes after malaria challenge using transcriptome and cellular profiling.

bioRxiv · Dec 9, 2022 · PreprintImmunology

The nucleoporin Nup170 mediates subtelomeric gene silencing through the Ctf18-RFC complex and PCNA

S. Kumar, M. L. Neal, S. Li, A. T. Navare, F. D. Mast, M. P. Rout, J. D. Aitchison

This study identifies Nup170's role in subtelomeric gene silencing by regulating PCNA levels through the Ctf18-RFC complex and Mlp1/Mlp2-dependent NPC subpopulations.

bioRxiv · Jun 17, 2022 · PreprintCell Biology

Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity

Y. Du, N. Hertoghs, J. Carnes, S. M. McDermott, M. L. Neal, K. V. Schwedhelm, M. J. McElrath, S. C. De Rosa, J. D. Aitchison, K. D. Stuart

The paper analyzes immune responses to malaria vaccination and finds that excessive early inflammation correlates with impaired immunity.

bioRxiv · Jul 28, 2021Immunology

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

F. D. Mast, P. C. Fridy, N. E. Ketaren, J. Wang, E. Y. Jacobs, J. P. Olivier, T. Sanyal, K. R. Molloy, F. Schmidt, M. Rutkowska, Y. Weisblum, L. M. Rich, E. R. Vanderwall, N. Dambrauskas, V. Vigdorovich, , M. P. Rout

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

bioRxiv · Apr 8, 2021Biochemistry

Autophagy as a mechanism for adaptive prediction-mediated emergence of drug resistance

N. Nivedita, J. D. Aitchison, N. S. Baliga

The paper shows that autophagy mutations linked to adaptive prediction confer drug tolerance and facilitate the emergence of drug resistance in yeast.

bioRxiv · Feb 2, 2021Evolutionary Biology

Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication

C. C. Carter, J. P. Olivier, A. Kaushansky, F. D. Mast, J. D. Aitchison

This study shows that dengue virus activates mTORC2 to prevent apoptosis and enhance viral replication.

bioRxiv · Sep 22, 2020Microbiology

A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.

K. Vijayan, N. Arang, L. Wei, R. Morrison, R. Geiger, R. K. Parks, A. J. Lewis, F. D. Mast, A. N. Douglass, H. S. Kain, J. D. Aitchison, J. S. Johnson, A. Aderem, A. Kaushansky

bioRxiv · Aug 31, 2020Cell Biology

ODELAM: Rapid sequence-independent detection of drug resistance in clinical isolates of Mycobacterium tuberculosis

T. Herricks, M. Donczew, F. Mast, T. Rustad, R. Morrison, T. R. Sterling, D. Sherman, J. D. Aitchison

ODELAM rapidly detects drug resistance in Mtb clinical isolates using time-lapse microscopy, identifying ofloxacin resistance and heteroresistance in 48 hours.

bioRxiv · Mar 17, 2020Microbiology

Plasmodium secretion induces hepatocyte lysosome exocytosis and promotes parasite entry

K. Vijayan, I. Cestari, F. D. Mast, E. K. K. Glennon, S. M. McDermott, H. S. Kain, A. M. Brokaw, J. D. Aitchison, K. Stuart, A. Kaushansky

This study shows that Plasmodium sporozoites induce hepatocyte lysosome exocytosis through secreted factors, facilitating parasite entry and highlighting parallels with Trypanosoma cruzi infection.

bioRxiv · Apr 25, 2019Cell Biology

ESCRT-III acts in scissioning new peroxisomes from the ER

F. D. Mast, T. Herricks, K. M. Strehler, L. R. Miller, R. A. Saleem, R. A. Rachubinski, J. D. Aitchison

This study identifies ESCRT-III proteins as essential for scissioning preperoxisomal vesicles from the ER during peroxisome biogenesis.

bioRxiv · Jan 19, 2018Cell Biology