Pharmacology & ToxicologybioRxiv
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
K. A. Fader, I. D. Pardo, R. C. Kovi…·M. P. Sirivelu
This study evaluates neurofilament light chain (NF-L) as a biomarker for AAV-induced dorsal root ganglia toxicity in rats and monkeys, showing strong correlation with lesion severity.
DOI 10.1016/j.omtm.2022.03.017