H. H. Wang

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

This paper describes a CRISPR RNA-guided transposase system for efficient bacterial genome engineering, including a computational tool for crRNA design and a protocol for multiplexed DNA insertion.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

This study investigates the spatiotemporal dynamics of microbial engraftment in the gut following fecal microbiota transplantation using a murine model.

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

This study evaluates neurofilament light chain (NF-L) as a biomarker for AAV-induced dorsal root ganglia toxicity in rats and monkeys, showing strong correlation with lesion severity.

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

The paper examines how molecular function constrains protein divergence over time, finding that sequence and structural similarities stabilize after ~1-2 billion years of evolution.