Cell BiologybioRxiv
Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors
J. S. Smith, T. F. Pack, A. Inoue…·S. Rajagopal
The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.
DOI 10.1126/science.aay1833