I. Choi

MDRepo - an open environment for data warehousing and knowledge discovery from molecular dynamics simulations

MDRepo provides an open repository for storing and analyzing molecular dynamics simulations to support drug discovery and structural biology research.

Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions

The paper shows that locomotion in mice shifts sensory dominance from auditory to visual during conflicts by altering neural circuits in the parietal cortex.

Effects of Alternative Splicing-Specific Knockdown of Tjp1 α+ by Rbm47 on Tight Junctions Assembly during Blastocyst Development

This study shows that selective knockdown of Tjp1 + via Rbm47 siRNA in mouse blastocysts does not impair blastocyst development or TJ permeability, indicating Tjp1 + is not essential for TJ assembly during early development.

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Three consecutive glycolysis enzymes are involved in autophagic flux regulation through monitoring nutrient availability

This study identifies three glycolysis enzymes (TPI, GAPC, PGK) that negatively regulate autophagy by monitoring nutrient availability through their interaction with ATG101.

Subcellular localization of GPCR kinases differentially modulate biased signaling at CXCR3

The paper shows GRKs translocate to endosomes after CXCR3 activation, with ligand-specific GRK recruitment affecting biased signaling.

Single-Cell Analysis Identifies Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

This study uses single-cell RNA sequencing to identify immune and smooth muscle cell populations in CTEPH thrombus, revealing inflammatory mechanisms and a potential therapeutic target.

Location bias contributes to functionally selective responses of biased CXCR3 agonists

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi:β-arrestin complexes

The paper shows that biased agonists of CXCR3 differentially drive the formation of Gi:β-arrestin complexes, independent of G protein signaling or β-arrestin recruitment.

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

This study screens 48 FDA-approved drugs for antiviral efficacy against SARS-CoV-2 and identifies 24 drugs with IC50 values between 0.1 M and 10 M, including niclosamide and ciclesonide.

ThiL is a valid antibacterial target that is essential for both thiamine biosynthesis and salvage pathway in Pseudomonas aeruginosa

This study demonstrates that ThiL is essential for thiamine biosynthesis and salvage in Pseudomonas aeruginosa and identifies inhibitors with potential antibacterial activity.

Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19

The paper screens FDA-approved drugs against a MERS-CoV isolate to identify potential therapies for COVID-19, finding several drugs with therapeutic indexes >6 and synergistic combinations.

Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.