PhysiologybioRxivPreprint
TRiPPing the sensors: The osmosensing pathway of Polycystin 2
K. M. Marquez-Nogueras, R. M. Knutila, V. Vuchkovska, I. Y. Kuo
This study identifies osmolarity as a physiological activator of ER-localized PC2 and shows that MAP4-dependent microtubule stabilization is required for PC2's role in osmosensing and urine concentration.
DOI 10.1101/2023.05.09.540007