J. A. Lednicky

This study shows niclosamide reduces SARS-CoV-2 replication by modulating lipophagy and lipid metabolism in infected cells.

The paper assesses DENV-4 transmission potential in Florida Ae. aegypti mosquitoes using field and lab strains, finding higher transmission from field mosquitoes and highlighting the importance of using local populations for accurate risk estimation.

This paper develops an in vitro model using cryopreserved human lung tissue to study SARS-CoV-2 infection and drug responses, revealing donor-specific heterogeneity in viral susceptibility and treatment outcomes.

This paper identifies ORF3a as a SARS-CoV-2 viroporin that activates the NLRP3 inflammasome by causing potassium efflux, leading to IL-1β expression and inflammation.

The paper identifies circulating DENV4 in Aedes aegypti mosquitoes without corresponding human cases, highlighting gaps in current surveillance methods.