S. Kang

Lipid droplet surface promotes three-dimensional morphological evolution of non-rhomboidal cholesterol crystals

This study shows how cholesterol crystals form non-rhomboidal shapes on lipid droplets and develop into three-dimensional sheet-like structures through interfacial transport and lipid droplet components.

MAGE-A4-Responsive Plasma Cells Promote Non-Small Cell Lung Cancer

The paper shows MAGE-A4 promotes NSCLC by recruiting IgA+ plasma cells, reducing tumor burden and enhancing T cell activity.

Characterization of Genome-wide Phylogenetic Conflict Uncovers Evolutionary Modes of Carnivorous Fungi

The paper uses phylogenomic analyses of 23 genomes to study evolutionary modes of carnivorous fungi, finding extensive phylogenetic discordance due to incomplete lineage sorting and non-vertical evolution.

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Picomolar-Level Sensing of Cannabidiol by Metal Nanoparticles Functionalized with Chemically Induced Dimerization Binders

This paper develops a method for detecting cannabidiol (CBD) at picomolar levels using gold nanoparticles functionalized with chemically induced dimerization binders, achieving high sensitivity and specificity in biological samples.

An end-to-end workflow for non-destructive 3D pathology

This paper provides an end-to-end workflow for non-destructive 3D pathology using light-sheet microscopy, focusing on fluorescent H&E analogs for preclinical and clinical studies.

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie Bandavirus in aged ferrets

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells

SEC-seq links cell secretions to transcriptomes, revealing VEGF-A secretion heterogeneity and a unique gene signature in MSCs with high secretion.

Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases

This study reveals the structural features and mechanism of Legionella OTU deubiquitinases, showing their unique extended helical lobe and cooperative chain cleavage activity.

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic niches

This study identifies hypoxia-driven immunosuppression in glioblastoma by tracking TAM dynamics and reveals niche factors that promote immunotolerant states and poor prognosis.

gamma aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammation

This study shows GAB controls T cell inflammation by acting as a bioenergetic and signaling gatekeeper through ABAT-dependent anaplerosis and GABA(A) receptor-mediated autocrine signaling.

Plasticity in stomatal behavior across a gradient of water supply is consistent among field-grown maize inbred lines with varying stomatal patterning

The study finds that stomatal conductance model parameters m and g1 are consistent across diverse maize genotypes under varying water supplies, suggesting flexibility in water use efficiency mechanisms.

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

This study shows that succinate dehydrogenase/complex II is essential for T cell proliferation and inflammation by regulating metabolic flux and epigenetic modifications.

Synthetic Nanobody-Functionalized Nanoparticles for Accelerated Development of Rapid, Accessible Detection of Viral Antigens

This paper introduces Nano2RED, a rapid, affordable diagnostic platform using nanobody-functionalized nanoparticles to detect viral antigens with high sensitivity and speed.

Transmission potential of Floridian Aedes aegypti mosquitoes for dengue virus serotype 4: Implications for estimating local dengue risk

The paper assesses DENV-4 transmission potential in Florida Ae. aegypti mosquitoes using field and lab strains, finding higher transmission from field mosquitoes and highlighting the importance of using local populations for accurate risk estimation.

Clustered Rapid Induction of Apoptosis Limits ZIKV and DENV-2 Proliferation in the Midguts of Aedes aegypti

The paper shows that rapid apoptosis in Aedes aegypti midgut cells limits DENV-2 and ZIKV proliferation, suggesting apoptosis as an antiviral defense mechanism.

Skeletal muscle DNMT3A plays a necessary role in endurance exercise by regulating oxidative capacity of red muscles

This study shows that DNMT3A in skeletal muscle regulates oxidative capacity and endurance exercise by controlling ROS production through ALDH1L1.

The integrin-mediated adhesome complex, essential to multicellularity, is present in the most recent common ancestor of animals, fungi, and amoebae

The paper shows the integrin-mediated adhesome complex existed in the common ancestor of animals, fungi, and amoebae, predating the evolution of Amoebozoa.

De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function.

This study shows that polyamine homeostasis in T cells is regulated by de novo synthesis and salvage pathways, affecting proliferation and function, with implications for inflammatory and autoimmune diseases.

Under-the-radar dengue virus infections in natural populations of Aedes aegypti mosquitoes

The paper identifies circulating DENV4 in Aedes aegypti mosquitoes without corresponding human cases, highlighting gaps in current surveillance methods.

Inosine is an alternative carbon supply that supports effector T cell proliferation and anti-tumor function under glucose restriction

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

The paper introduces a multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues using various clearing protocols.

Computational drug repositioning of bortezomib to reverse metastatic effect of GALNT14 in lung cancer

This study uses in silico drug repositioning to identify bortezomib as an inhibitor of GALNT14-driven lung cancer metastasis, validated through in vitro and in vivo experiments.

Dental restoration longevity among geriatric and adult special needs patients

This study examines the longevity of dental restorations in geriatric and adult special needs patients over 15 years, finding median survival of 6.25 years and factors associated with restoration failure.