Author

T. Garrett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cancer Biology· 2 Immunology· 2 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 4 Organism:C. elegans· 3 Assay:metabolomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

A. K. Sharma· 3 shared A. L. Coleman-Hulbert· 3 shared B. Onken· 3 shared C. A. Sedore· 3 shared D. Hall· 3 shared E. Chen· 3 shared E. Johnson· 3 shared G. Harinath· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

A. K. Sharma

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Author profile →

10 papers

Recent·Most cited

Intestinal serotonergic vagal signaling as a mediator of microbiota-induced hypertension

A. de Araujo, H. Sree Kumar, T. Yang, A. Alviter Plata, E. W. Dirr, N. Bearss, D. M. Baekey, D. S. Miller, B. Donertas-Ayaz, N. Ahmari, A. Singh, A. L. Kalinoski, T. Garrett, C. J. Martyniuk, G. de Lartigue, J. Zubcevic

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

bioRxiv · Jul 17, 2024Physiology

Pharmacologic Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm Formation

J. R. Krebs, P. Bellotti, J. A. C. Valisno, G. Su, S. Sharma, D. J. M. Kollareth, J. Hartman, A. Adithan, M. Spinosa, M. Kamat, T. Garrett, G. Cai, A. K. Sharma, G. R. Upchurch

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

bioRxiv · Jun 18, 2024 · PreprintImmunology

Lipoxin A4/FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury

D. Manual, V. Leroy, Z. Tu, M. Woolet-Stockton, M. Kamat, T. Garrett, C. Atkinson, G. Cai, G. R. Upchurch, A. K. Sharma

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

bioRxiv · Apr 22, 2024Immunology

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

S. A. Banse, E. G. Jackson, C. A. Sedore, B. Onken, D. Hall, A. L. Coleman-Hulbert, P. Huynh, T. Garrett, E. Johnson, G. Harinath, D. Inman, S. Guo, M. Morshead, J. Xue, R. Falkowski, , P. C. Phillips

This study evaluates how compound interventions and genetic background affect healthspan and lifespan in C. elegans under stress conditions.

bioRxiv · Jan 15, 2022Physiology

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

S. A. Banse, C. A. Sedore, E. Johnson, A. L. Coleman-Hulbert, B. Onken, D. Hall, E. G. Jackson, P. Huynh, A. C. Foulger, S. Guo, T. Garrett, J. Xue, D. Inman, M. L. Morshead, W. T. Plummer, , P. C. Phillips

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

bioRxiv · Nov 9, 2021Physiology

Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

S. Narayan, A. Raza, I. Mahmud, N. Koo, T. Garrett, M. E. Law, B. K. Law, A. K. Sharma

This study identifies NSC49L as a PP2A agonist that sensitizes FOLFOX-resistant colorectal cancer cells to TRAIL by downregulating the AKT1/mTOR/4EBP1-axis and p21 translation.

bioRxiv · Jul 21, 2021Cancer Biology

Niclosamide reverses SARS-CoV-2 control of lipophagy

T. Garrett, H. Coatsworth, I. Mahmud, T. Hamerly, C. J. Stephenson, H. Yazd, J. B. Ayers, M. Miller, J. A. Lednicky, R. R. Dinglasan

This study shows niclosamide reduces SARS-CoV-2 replication by modulating lipophagy and lipid metabolism in infected cells.

bioRxiv · Jul 11, 2021 · PreprintMicrobiology

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

S. A. Banse, M. Lucanic, C. A. Sedore, A. L. Coleman-Hulbert, W. T. Plummer, E. Chen, J. L. Kish, D. Hall, B. Onken, M. P. Presley, E. G. Jones, B. W. Blue, T. Garrett, M. Abbott, J. Xue, , P. C. Phillips

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

bioRxiv · Sep 14, 2019Physiology

Re-modeling of foliar membrane lipids in a seagrass allows for growth in phosphorus deplete conditions

J. Koelmel, J. Campbell, L. E. Meke, J. Guingab-Cagmat, T. Garrett, U. Stingl

The paper analyzes lipidome changes in seagrass leaves under high and low phosphorus conditions, identifying lipid species that adjust to phosphorus availability.

bioRxiv · Jun 10, 2019Ecology

Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery

B. Lee, I. Mahmud, J. Marchica, P. Derezinski, F. Qi, F. Wang, P. Joshi, F. Valerio, I. Rivera, V. Patel, C. P. Pavlovich, T. Garrett, G. P. Schroth, Y. Sun, R. J. Perera

The paper identifies urine-enriched RNAs and metabolites in prostate cancer patients and normal individuals, revealing altered glutamate metabolism and TCA cycle in cancer cells.

bioRxiv · Apr 4, 2019Cancer Biology