Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden
R. Salehi-Rad, R. Li, L. M. Tran, R. J. Lim, J. Abascal, M. Momcilovic, S. J. Park, S. L. Ong, Z. L. Huang, M. Paul, D. B. Shackelford, K. Krysan, B. Liu, S. M. Dubinett
This paper develops novel Kras-mutant murine NSCLC models with increased TMB and co-occurring mutations, showing enhanced anti-PD-1 efficacy but immunosuppressed TMEs in some models.
bioRxiv · Feb 15, 2020Cell Biology