Author

K. Krysan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. M. Dubinett· 3 shared A. E. Spira· 2 shared B. Liu· 2 shared H. Kadara· 2 shared J. Beane· 2 shared J. D. Campbell· 2 shared L. M. Tran· 2 shared M. E. Lenburg· 2 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

S. M. Dubinett

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-cell characterization of subsolid and solid lesions in the lung adenocarcinoma spectrum

J. Yanagawa, L. M. Tran, E. Fung, W. D. Wallace, A. E. Prosper, G. A. Fishbein, C. Shea, R. Hong, B. Liu, R. Salehi-Rad, J. Z. Deng, A. Gower, J. D. Campbell, S. A. Mazzilli, J. Beane, , S. M. Dubinett

The paper uses single-cell RNA sequencing to compare immune and non-immune cell features in subsolid, solid, and non-involved lung tissues, finding reduced cytolytic activity and increased regulatory T cells in subsolid lesions.

bioRxiv · Dec 25, 2020 · PreprintCancer Biology

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

A. Sinjab, G. Han, W. Treekitkarnmongkol, K. Kobayashi, P. Brennan, M. Dang, D. Hao, R. Wang, E. Dai, H. Dejima, J. Zhang, E. Bogatenkova, B. Sanchez-Espiridion, K. Chang, D. R. Little, , H. Kadara

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden

R. Salehi-Rad, R. Li, L. M. Tran, R. J. Lim, J. Abascal, M. Momcilovic, S. J. Park, S. L. Ong, Z. L. Huang, M. Paul, D. B. Shackelford, K. Krysan, B. Liu, S. M. Dubinett

This paper develops novel Kras-mutant murine NSCLC models with increased TMB and co-occurring mutations, showing enhanced anti-PD-1 efficacy but immunosuppressed TMEs in some models.

bioRxiv · Feb 15, 2020Cell Biology

Molecular Subtyping reveals Immune Alterations associated with Progression of Bronchial Premalignant Lesions

J. Beane, S. A. Mazzilli, J. D. Campbell, G. Duclos, K. Krysan, C. Moy, C. Perdomo, M. Schaffer, G. Liu, S. Zhang, H. Liu, J. Vick, S. S. Dhillon, S. J. Platero, S. M. Dubinett, , A. E. Spira

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.

bioRxiv · Sep 12, 2018Cancer Biology