Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization
D. Jahn, P. R. Knapstein, E. Otto, P. Köhli, J. Sevecke, F. Graef, C. Graffmann, M. Fuchs, S. Jiang, M. Rickert, C. Erdmann, J. Appelt, L. Revend, Q. Küttner, J. Witte, , J. Keller
This study identifies beta2-adrenergic signaling as a key driver of bone healing by enhancing callus neovascularization, with implications for therapeutic strategies and the risks of beta-blockers.
bioRxiv · Jul 14, 2023Cell Biology