M. Fuchs

SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation

This study shows SGLT2 inhibitors reduce endothelial to mesenchymal transition and cardiac fibroblast activation through effects on mitochondrial respiration, actin cytoskeleton, and specific transporters.

Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH

This paper identifies PrdH as the maturation enzyme required for the formation of the pyruvoyl group in the proline reductase Prd of C. difficile, essential for proline utilization and toxin production.

ASBAR: an Animal Skeleton-Based Action Recognition framework. Recognizing great ape behaviors in the wild using pose estimation

ASBAR classifies great ape behaviors in the wild using pose estimation and achieves 75.3% Top-1 accuracy with reduced data size.

Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization

This study identifies beta2-adrenergic signaling as a key driver of bone healing by enhancing callus neovascularization, with implications for therapeutic strategies and the risks of beta-blockers.

Characterization of cotton virus A, a novel and distinct member of the genus Caulimovirus with endogenous viral elements in Gossypium spp.

The paper characterizes cotton virus A, a new Caulimovirus, and identifies endogenous viral elements in some cotton species.

VPRBP functions downstream of the androgen receptor and OGT to restrict p53 activation in prostate cancer

This study identifies VPRBP as a co-regulator of the androgen receptor and OGT that suppresses p53 activation in prostate cancer, linking its expression to poor clinical outcomes.

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.

An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important Gram-positive bacterium

This study maps the transcriptome of C. difficile and reveals Hfq's role in post-transcriptional regulation through RNA-centric techniques and Hfq RIP-seq.