Author

J. Ashton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Jones· 2 shared J. R. Myers· 2 shared M. T. Milano· 2 shared N. Khazan· 2 shared R. K. Singh· 2 shared R. Moore· 2 shared R. Pandita· 2 shared T. Conley· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Jones

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

J. S. Chavez, J. L. Rabe, D. Loeffler, K. Higa, G. Hernandez, T. S. Mills, N. Ahmed, R. L. Gessner, Z. Ke, B. M. Idler, H. M. Kim, J. R. Myers, B. M. Stevens, C. T. Jordan, H. Nakajima, , E. M. Pietras

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Journal of Experimental Medicine · Apr 15, 2021Peer-reviewedImmunology

Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse

J. Kallenbach, M. Freeberg, D. Abplanalp, J. Lillis, J. Ashton, A. E. Loiselle, M. Buckley, A. van Wijnen, H. A. Awad

The study compares tendon healing in MRL/MpJ and C57Bl/6J mice, finding altered TGFB1 pathways in MRL mice that reduce fibrosis and promote faster healing.

bioRxiv · Feb 8, 2021Cell Biology

Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently

R. K. Singh, K. Kim, R. B. Rowswell-Turner, J. N. Hansen, N. Khazan, A. Jones, U. Sivagnanalingam, Y. Teramoto, T. Goto, Y. Jian, N. Battaglia, T. Conley, V. Hovanesian, N. Yano, R. Pandita, , R. Moore

This study shows that MeTC7, a VDR antagonist, reduces PD-L1 expression in cancer cells and inhibits neuroblastoma growth independently of PD-L1.

bioRxiv · Aug 16, 2020 · PreprintCancer Biology

Septins disruption controls tumor growth and enhances efficacy of Herceptin

R. K. Singh, K. K. Kim, N. Khazan, R. B. Rowswell_Turner, C. Laggner, A. Jones, P. Srivastava, V. Hovanesian, L. Lamere, T. Conley, R. Pandita, C. Baker, J. R. Myers, E. Prichett, A. Awada, , R. Moore

The paper develops UR214-9, a compound that disrupts septin filaments in cancer cells, inhibiting growth of HER2+ tumors and enhancing Herceptin efficacy.

bioRxiv · Feb 19, 2020 · PreprintCancer Biology