Author

J. Bednarsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

T. Luedde· 5 shared S. Sivakumar· 4 shared X. Tan· 4 shared F. Rocha· 3 shared J. Garcia Vallejo· 3 shared L. R. Heij· 3 shared S. Lang· 3 shared U. Neumann· 3 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

T. Luedde

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5 papers

Recent·Most cited

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

L. R. Heij, S. Hayat, K. Reichel, S. Maryam, C. Rourke, X. Tan, M. van den Braber, J. Verhoeff, M. Halder, F. Peisker, G. Wiltberger, J. Bednarsch, D. Heise, J. Campello Deierl, S. Lang, , U. Neumann

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

bioRxiv · Feb 3, 2024Cancer Biology

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

L. Heij, K. Reichel, W. de Koning, J. Bednarsch, X. Tan, J. Campello Deierl, M. Clahsen-van Groningen, T. Al-Masri, R. van Dam, J. Garcia Vallejo, F. Ulmer, S. Lang, T. Luedde, F. Rocha, E. Dahl, , U. Neumann

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

bioRxiv · Aug 14, 2023 · PreprintCancer Biology

Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signaling

M. Paluschinski, J. Schira-Heinen, R. Pellegrino, L. R. Heij, J. Bednarsch, U. P. Neumann, T. Longerich, K. Stuehler, T. Luedde, M. Castoldi

This study identifies miR-122's role in liver disease by showing its antagonistic effects on NRF1 and E2F4 and its impact on proteins linked to malignancy.

bioRxiv · Jun 30, 2023Cancer Biology

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

X. Tan, M. Rosin, S. Appinger, J. Bednarsch, D. Liu, G. Wiltberger, J. Garcia Vallejo, S. Jang, Z. Czigany, S. Boroojerdi, N. Gaisa, P. Boor, R. Buelow, J. de Vos-Geelen, L. Valkenburg-van Iersel, , L. Heij

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

L. R. Heij, X. Tan, J. N. Kather, J. M. Niehues, S. Sivakumar, N. Heussen, G. van der Kroft, S. W. M. Olde Damink, S. Lang, J. Bednarsch, M. R. Aberle, T. Luedde, N. Gaisa, D. H. W. Liu, J. P. M. Cleutjens, , U. P. Neumann

The paper analyzes nerve fiber density and tertiary lymphoid structures in pancreatic cancer, finding that high nerve fiber density and TLS count correlate with improved survival.

bioRxiv · Aug 7, 2020 · PreprintCancer Biology