Author

L. Heij

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

S. Sivakumar· 3 shared F. Rocha· 2 shared G. Wiltberger· 2 shared J. Bednarsch· 2 shared J. Garcia Vallejo· 2 shared M. Clahsen-van Groningen· 2 shared T. Luedde· 2 shared U. Neumann· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

S. Sivakumar

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3 papers

Recent·Most cited

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

S. Sivakumar, A. Jainarayanan, E. Arbe-Barnes, M. N. Leathlobhair, P. K. Sharma, S. Amin, L. Heij, S. Hegde, A. Magen, F. Tucci, B. Sun, S. Wu, N. M. Anand, H. Slawinski, S. Revale, , R. J. M. Bashford-Rogers

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

bioRxiv · Aug 31, 2023 · PreprintImmunology

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

L. Heij, K. Reichel, W. de Koning, J. Bednarsch, X. Tan, J. Campello Deierl, M. Clahsen-van Groningen, T. Al-Masri, R. van Dam, J. Garcia Vallejo, F. Ulmer, S. Lang, T. Luedde, F. Rocha, E. Dahl, , U. Neumann

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

bioRxiv · Aug 14, 2023 · PreprintCancer Biology

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

X. Tan, M. Rosin, S. Appinger, J. Bednarsch, D. Liu, G. Wiltberger, J. Garcia Vallejo, S. Jang, Z. Czigany, S. Boroojerdi, N. Gaisa, P. Boor, R. Buelow, J. de Vos-Geelen, L. Valkenburg-van Iersel, , L. Heij

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology