F. Rocha

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

Quantification of surface tension effects and nucleation-and-growth rates during self-assembly of biological condensates

The paper derives a kinetic solution to predict biological condensate formation by considering surface tension and nucleation-growth rates, showing large condensates can form without size control mechanisms.

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

Submandibular Injection of Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein Inhibits and Prevents Periodontal Disease Progression Over 12 Weeks

This study shows that submandibular injection of IDO-Gal3 fusion protein prevents and halts periodontal disease progression by modulating immune responses and reducing bone loss.

Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation

This paper develops a fusion protein IDO-Gal3 that anchors immunosuppressive enzymes to tissues, effectively suppressing local inflammation in multiple disease models.

A simple linearization method unveils hidden enzymatic assay interferences

This paper introduces a linearization method to detect hidden enzymatic assay interferences by analyzing progress curves in modified coordinates, improving the accuracy of kinetic data selection.