S. Lang

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

Application of an NMR/crystallography fragment screening platform for the assessment and rapid discovery of new HIV-CA binding fragments

The paper uses NMR and crystallography to identify and assess new HIV-CA binding fragments, leading to the discovery of two compounds with improved binding properties.

The Quest to Identify USP8 Inhibitors for Parkinsons Disease, a PAINful Experience.

The paper identifies PAINS in a USP8 inhibitor screening campaign for Parkinson's disease and discusses interference mechanisms affecting assay reliability.

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

ExMove: An open-source toolkit for processing and exploring animal tracking data in R

ExMove provides an open-source R toolkit for processing and exploring animal tracking data, enhancing reproducibility and standardization in movement ecology.

Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

The paper identifies substrates and a novel component, hSnd3, in the hSnd2-dependent ER protein targeting pathway through proteomic analysis.

Utilizing multi-objective decision support tools for protected area selection

This paper presents a global decision support tool for selecting protected areas by balancing multiple conservation objectives and highlighting trade-offs among them.

Single-cell RNA sequencing identifies phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow

The paper uses single-cell RNA sequencing to identify six distinct stromal cell populations in human bone marrow and their roles in hematopoiesis.

Adaptive subsets limit the anti-tumoral NK-cell activity in Hepatocellular Carcinoma

This study shows that adaptive NK cells have reduced anti-tumoral activity in HCC patients, particularly in those with HBV infection, and are expanded in such cases.

CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

The paper analyzes nerve fiber density and tertiary lymphoid structures in pancreatic cancer, finding that high nerve fiber density and TLS count correlate with improved survival.

Prion Protein Folding Mechanism Revealed by Pulling Force Studies

This study uses pulling force measurements to reveal how specific sequences in the prion protein modulate translocation forces and contribute to toxic topologies during synthesis.

LegoBody: facile generation of bispecific and multi-specific antibodies

This study introduces a modular method to generate bispecific and multi-specific antibodies using temporary linkers and proteases, enabling efficient production with desired properties.

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.

Genome rearrangements induce biofilm formation in Escherichia coli C, an old model organism with a new application in biofilm research

This paper presents the complete genome of E. coli C, identifies genomic differences linked to biofilm formation, and shows its potential as a model for biofilm research.

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

The paper identifies a transiently exposed epitope on influenza H7 hemagglutinin that is targeted by a potent neutralizing monoclonal antibody.

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

This study shows that the EBI2-7,25-dihydroxycholesterol axis is induced in colitis and promotes lymphoid structure accumulation during homeostasis and inflammation.