J. Borowsky

Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains Kras mutant intestinal neoplasia

This study compares Kras and Braf mutant intestinal neoplasia in mice, showing Kras mutations lead to less aggressive serrated lesions with reduced WNT signaling activation and attenuated DNA methylation changes compared to Braf mutations.

Predicting the locations of cryptic pockets from single protein structures using the PocketMiner graph neural network

The paper introduces PocketMiner, a graph neural network that predicts cryptic pockets in proteins, identifying them accurately and rapidly, expanding the druggable proteome.

Aspirin synergizes with regorafenib to reduce growth of colorectal cancer

This study shows that aspirin and regorafenib together reduce colorectal cancer growth in preclinical models by inhibiting the PI3K-Akt-mTOR pathway and activating AMPK.

Tumor-Immune Partitioning and Clustering (TIPC) algorithm reveals distinct signatures of tumor-immune cell interactions within the tumor microenvironment

The paper introduces TIPC, a computational algorithm that identifies tumor-immune spatial patterns in colorectal cancer, linking them to patient survival and tumor features.