Author

D. Mckeone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:diffusion model· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Kane· 2 shared B. Leggett· 2 shared C. Liu· 2 shared A.-M. Patch· 1 shared C. Bond· 1 shared C. E. Bond· 1 shared C. Su· 1 shared J. Borowsky· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Kane

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains Kras mutant intestinal neoplasia

L. J. Fennell, S. Tria, C. Liu, A. Kane, D. McKeone, J. Borowsky, L. Chai, S. Randall-demllo, C. E. Bond, B. Leggett, V. L. Whitehall

This study compares Kras and Braf mutant intestinal neoplasia in mice, showing Kras mutations lead to less aggressive serrated lesions with reduced WNT signaling activation and attenuated DNA methylation changes compared to Braf mutations.

bioRxiv · Dec 21, 2023 · PreprintCancer Biology

APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers

L. Fennell, A. Kane, C. Liu, D. Mckeone, W. Fernando, C. Su, C. Bond, S. Jamieson, T. Dumenil, A.-M. Patch, S. Kazakoff, J. Pearson, N. Waddell, B. Leggett, V. Whitehall

This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.

bioRxiv · Feb 16, 2020Cancer Biology