Pharmacology & ToxicologybioRxivPreprint
Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice
D. R. Robarts, D. Paine-Cabrera, M. Kotulkar…·U. Apte
This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.
DOI 10.1101/2023.02.01.526711