Author

M. Kotulkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

U. Apte· 5 shared D. Paine-Cabrera· 4 shared D. R. Robarts· 3 shared C. Slawson· 2 shared D. Robarts· 2 shared J. A. Hanover· 2 shared K. K. Venneman· 2 shared N. E. Zachara· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersPathology

U. Apte

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Author profile →

5 papers

Recent·Most cited

Role of HNF4alpha-cMyc Interaction in CDE-diet Induced Liver Injury and Regeneration

M. Kotulkar, J. Barbee, D. Robarts, D. Paine-Cabrera, U. Apte

This study examines the role of HNF4-cMyc interaction in liver injury and regeneration using a CDE diet model, finding that HNF4 deletion increases injury while cMyc deletion decreases it, with combined deletion leading to a unique HPC activation phenotype.

bioRxiv · Nov 27, 2023Pathology

Regulation of Hepatic Xenosensor Function by HNF4alpha

M. Kotulkar, D. Paine-Cabrera, D. Robarts, U. Apte

This study shows that HNF4alpha is essential for the function of CAR, PXR, and PPAR but not AhR in hepatic xenosensor activation.

bioRxiv · Oct 11, 2023Pharmacology & Toxicology

The Essential Role of O-GlcNAcylation in Hepatic Differentiation

D. R. Robarts, M. Kotulkar, D. Paine-Cabrera, K. K. Venneman, J. A. Hanover, N. E. Zachara, C. Slawson, U. Apte

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

bioRxiv · Feb 16, 2023Pathology

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

D. R. Robarts, D. Paine-Cabrera, M. Kotulkar, K. K. Venneman, S. Gunewardena, J. C. Corton, C. Lau, L. Foquet, G. Bial, U. Apte

This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.

bioRxiv · Feb 1, 2023 · PreprintPharmacology & Toxicology

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

D. R. Robarts, S. R. McGreal, D. S. Umbaugh, W. S. Parkes, M. Kotulkar, S. Abernathy, N. Lee, H. Jaeschke, S. Gunewardena, S. A. Whelan, J. A. Hanover, N. E. Zachara, C. Slawson, U. Apte

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.

bioRxiv · Oct 14, 2021Pathology