De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma
J. M. Shireman, F. Atashi, G. Lee, E. Ali, M. Saathoff, C. Park, S. Baiswala, J. Miska, M. Lesniak, J. C. David, R. Stupp, P. Kumthekar, C. Horbinski, I. Ben-Sahar, A. U. Ahmed
This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.
Brain · Apr 14, 2021Peer-reviewedCancer Biology