Cancer BiologybioRxiv
TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
J. Verhoeven, K. A. Jacobs, F. Rizzollo…·P. Agostinis
This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.