Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway
P. Wei, A. J. Bott, A. A. Cluntun, J. T. Morgan, C. N. Cunningham, J. C. Schell, Y. Ouyang, S. B. Ficarro, J. A. Marto, N. N. Danial, R. J. DeBerardinis, J. Rutter
This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.
bioRxiv · Aug 26, 2021 · PreprintCancer Biology