P. Wei

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

MiceVAPORDot: A novel automated approach for high-throughput behavioral characterization during E-cigarette exposure in mice

MiceVAPORDot automates behavioral analysis during e-cigarette exposure in mice, revealing phenotypes not detectable by traditional methods.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

A cataract-causing Y204X mutation of CRYβB1 promotes C-terminal degradation and higher-order oligomerization

This study identifies a cataract-causing mutation in CRYβB1 that leads to C-terminal truncation, increased proteolysis, and higher-order oligomerization, contributing to lens opacity.

Structural and functional analysis of lorlatinib analogs reveals roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer

This study identifies lorlatinib-resistant ALK mutations and evaluates analogs to develop targeted therapies for compound resistance in ALK-positive lung cancer.

Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway

This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.

The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

The basis of a more contagious 501Y.V1 variant of SARS-COV-2

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors

The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.

A Hierarchical 3D-motion Learning Framework for Animal Spontaneous Behavior Mapping

This paper introduces a hierarchical 3D-motion learning framework to map animal spontaneous behavior by capturing kinematics and learning dynamic behavior patterns.

Antagonistic crosstalk fine-tunes sensitivities of IRE1 and PERK signaling during unfolded protein response

The paper studies how IRE1 and PERK signaling branches coordinate during ER stress, finding mutual inhibition and differential sensitivity regulated by p58IPK.

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.