Author

J. Chappell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. C. Sims· 1 shared A. Finigan· 1 shared A. J. Brown· 1 shared A. K. Uryga· 1 shared A. Kolykhalov· 1 shared A. L. Taylor· 1 shared A. Pruijssers· 1 shared A. Schaefer· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperMicrobiology

A. C. Sims

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Primed smooth muscle cells acting as first responder cells in disease

M. D. Worssam, J. Lambert, S. Oc, A. L. Taylor, L. Dobnikar, J. Chappell, J. L. Harman, N. L. Figg, A. Finigan, K. Foote, A. K. Uryga, M. R. Bennett, M. spivakov, H. Jorgensen

This study identifies SCA1+ vascular smooth muscle cells as first responders that drive clonal proliferation in vascular injury and atherosclerosis.

bioRxiv · Oct 19, 2020Cell Biology

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

T. P. Sheahan, A. C. Sims, S. Zhou, C. Hill, S. R. Leist, A. Schaefer, M. Agostini, A. Pruijssers, A. J. Brown, G. Bluemling, M. Natchus, M. Saindane, A. Kolykhalov, G. Painter, R. Swanstrom, , R. S. Baric

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

bioRxiv · Mar 19, 2020 · PreprintMicrobiology

Pericyte Bridges in Homeostasis and Hyperglycemia: Reconsidering Pericyte Dropout and Microvascular Structures

B. A. Corliss, H. C. Ray, R. Doty, C. Mathews, N. Sheybani, K. Fitzgerald, R. Prince, M. Kelly-Goss, W. L. Murfee, J. Chappell, G. Owens, P. A. Yates, S. M. Peirce

The paper reevaluates pericyte dropout in diabetic retinopathy, showing pericyte bridges are misclassified and highlighting their role in disease progression.

bioRxiv · Jul 16, 2019 · PreprintCell Biology