Author

J. Gordan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. T. Webber· 2 shared R. S. Levin· 2 shared S. Bandyopadhyay· 2 shared A. Choi· 1 shared A. Goga· 1 shared A. Pitea· 1 shared B. C. Pascual· 1 shared D. E. Kaplan· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

J. T. Webber

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Author profile →

4 papers

Recent·Most cited

Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts

K. Weinfurtner, D. Tischfield, G. McClung, J. Crainic, J. Gordan, J. Jiao, E. E. Furth, W. Li, E. Tuzneen Supan, G. J. Nadolski, S. J. Hunt, D. E. Kaplan, T. P. Gade

This study shows that human GM-CSF and IL-3 expression in humanized mice increases immune cell infiltration in HCC tumors, improving the model's resemblance to human disease.

bioRxiv · Oct 5, 2023Cancer Biology

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

S. M.-L. Lauer, M. H. Omar, M. G. Golkowski, H. L. Kenerson, B. C. Pascual, K. Forbush, F. D. Smith, J. Gordan, S.-E. M. Ong, R. S. Yeung, J. D. Scott

This study identifies BAG2 as a key player in DNAJ-PKAc-mediated chemotherapeutic resistance in fibrolamellar carcinoma by linking it to Hsp70 and Bcl-2.

bioRxiv · Jun 28, 2023Cancer Biology

HBV rewires liver cancer signaling by altering PP2A complexes

A. Pitea, R. Turnham, M. Eckhardt, G. M. Jang, Z. Xu, H. C. Lim, A. Choi, J. Von Dollen, R. S. Levin, J. T. Webber, E. McCarthy, J. Hu, X. Li, L. Che, G. Chan, , J. Gordan

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

bioRxiv · Mar 15, 2023 · PreprintCancer Biology

Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer

H. J. Donnella, J. T. Webber, R. S. Levin, R. Camarda, O. Momcilovic, N. Bayani, K. N. Shah, J. Korkola, K. M. Shokat, A. Goga, J. Gordan, S. Bandyopadhyay

The paper identifies AURKA as a barrier to PI3K/mTOR inhibitor efficacy in breast cancer by mapping kinome dynamics and showing that AURKA inhibition synergizes with these drugs to induce apoptosis and tumor regression.

bioRxiv · Jun 30, 2017Cancer Biology