J. D. Sutherland

Initial amino acid:codon assignments and strength of codon:anticodon binding

The paper investigates codon:anticodon binding strengths and suggests that family box codons may have been used in early peptide synthesis due to tighter binding and simultaneous codon recognition.

BioE3 enables the identification of bona fide targets of E3 ligases

BioE3 identifies substrates of UbL E3 ligases by site-specific biotinylation and proteomic analysis, revealing both known and novel targets for various E3 ligases.

Potentially prebiotic synthesis of aminoacyl-RNA via a bridging phosphoramidate-ester intermediate

This paper describes a prebiotically plausible mechanism for aminoacyl-RNA synthesis using phosphoramidate-ester intermediates and mild acid hydrolysis.

Identification of proximal SUMO-dependent interactors using SUMO-ID

This study introduces SUMO-ID, a method to identify SUMO-dependent protein interactors using TurboID and protein-fragment complementation, revealing novel interactions related to transcription, DNA damage, and stress response.

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome

The paper identifies LUZP1 as a regulator of primary cilia and actin cytoskeleton, showing its role in Townes-Brocks Syndrome through interactions with SALL1 and effects on ciliogenesis and Sonic Hedgehog signaling.