C. Perez

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma

The paper identifies novel IL13Rα2-targeted CARs with improved anti-glioblastoma efficacy using a pooled screening platform.

The function of CozE proteins is linked to lipoteichoic acid biosynthesis in Staphylococcus aureus

This study identifies CozE proteins as regulators of lipoteichoic acid biosynthesis and membrane homeostasis in Staphylococcus aureus through genetic and biochemical analyses.

BioE3 enables the identification of bona fide targets of E3 ligases

BioE3 identifies substrates of UbL E3 ligases by site-specific biotinylation and proteomic analysis, revealing both known and novel targets for various E3 ligases.

Hep3D: A 3D single-cell digital atlas of the liver to study spatio-temporal tissue architecture

The paper develops Hep3D, a 3D single-cell atlas of the mouse liver, revealing spatiotemporal patterns of cellular structures and the structural role of Kupffer cells in liver homeostasis.

Higher social tolerance is associated with more complex facial behavior in macaques

The study finds that crested macaques, which are more socially tolerant, exhibit higher facial behavior diversity and complexity compared to less tolerant macaque species.

Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

This study shows that competence in Streptococcus pneumoniae is crucial for virulence by increasing surface exposure of virulence factors and providing resistance to fratricide.

The global distribution and environmental drivers of the soil antibiotic resistome

This study maps the global distribution of antibiotic resistance genes in soils and identifies key environmental drivers influencing their prevalence.

Osmotic stress response in BetP: How lipids and K+ team up to overcome downregulation

This study investigates how K+ and lipids regulate BetP's osmotic stress response by analyzing structural changes and K+ interactions in BetP.

Digital control of c-di-GMP in E. coli balances population-wide developmental transitions and phage sensitivity

This study shows E. coli uses a digital switch to convert c-di-GMP dynamics into binary states, enabling population-level developmental transitions and phage resistance.

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification

This study characterizes the structure and function of LicB, a choline transporter in Streptococcus pneumoniae, revealing its proton-coupled import mechanism and potential as a target for inhibition.

Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter

This study investigates the mechanism of LtaA, a proton-dependent MFS lipid transporter, revealing a trap-and-flip mechanism for lipid translocation.

Evolution of the quorum sensing regulon in cooperating populations of Pseudomonas aeruginosa

The paper shows that long-term growth of Pseudomonas aeruginosa under limited QS conditions reduces the number of QS-activated genes by 45-70%.

Identification of proximal SUMO-dependent interactors using SUMO-ID

This study introduces SUMO-ID, a method to identify SUMO-dependent protein interactors using TurboID and protein-fragment complementation, revealing novel interactions related to transcription, DNA damage, and stress response.

Single cell transfection of human induced pluripotent stem cells using a droplet-based microfluidic system.

The paper presents a droplet-based microfluidic system for transfecting human-induced pluripotent stem cells, showing high efficiency and cost-effectiveness compared to other methods.

Proteolytic program-dependent functions are impaired in INF2-mediated focal segmental glomerulosclerosis.

This study identifies a proteolytic cleavage mechanism in INF2 that affects its function in podocytes, leading to impaired localization and contributing to FSGS.