Cancer BiologybioRxiv
Modeling the MYC-driven normal-to-tumour switch in breast cancer.
C. Lourenco, M. Kalkat, K. E. Houlahan…·L. Z. Penn
This study creates an in vivo model of MYC-driven breast cancer by combining PIK3CAH1047R mutation with deregulated MYC, showing a normal-to-tumour switch and dependence on MYC for tumor growth.
DOI 10.1242/dmm.038083