Author

J. Longo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

L. Z. Penn· 2 shared R. G. Jones· 2 shared R. Sheldon· 2 shared A. Kupai· 1 shared A.-C. Gingras· 1 shared B. Haibe-Kains· 1 shared B. M. Dickson· 1 shared B. M. Oswald· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

L. Z. Penn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

J. H. Schofield, J. Longo, R. Sheldon, E. Albano, M. A. Hawk, S. Murphy, L. Duong, S. Rahmy, X. Lu, R. G. Jones, Z. T. Schafer

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

bioRxiv · Sep 14, 2023Cancer Biology

SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism

C. Zhang, M. Shafaq-Zadah, J. Pawling, G. G. Hesketh, D. Ng, E. Dransart, K. Pacholczyk, J. Longo, A.-C. Gingras, L. Z. Penn, L. Johannes, J. W. Dennis

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

bioRxiv · Nov 15, 2022 · PreprintCell Biology

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

K. M. Luda, S. M. Kitchen-Goosen, E. H. Ma, M. J. Watson, L. R. Duimstra, B. M. Oswald, J. Longo, Z. Fu, Z. Madaj, A. Kupai, B. M. Dickson, I. Kaymak, K. Lau, S. Compton, L. M. DeCamp, , R. G. Jones

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

bioRxiv · Aug 26, 2022 · PreprintImmunology

Computational pharmacogenomics screen identifies synergistic statin-compound combinations as anti-breast cancer therapies

J. E. van Leeuwen, W. Ba-Alawi, E. Branchard, J. Longo, J. Silvester, D. W. Cescon, B. Haibe-Kains, L. Penn, D. Gendoo

bioRxiv · Sep 7, 2020 · PreprintCancer Biology

Modeling the MYC-driven normal-to-tumour switch in breast cancer.

C. Lourenco, M. Kalkat, K. E. Houlahan, J. De Melo, J. Longo, S. J. Done, P. C. Boutros, L. Z. Penn

This study creates an in vivo model of MYC-driven breast cancer by combining PIK3CAH1047R mutation with deregulated MYC, showing a normal-to-tumour switch and dependence on MYC for tumor growth.

bioRxiv · Aug 20, 2018Cancer Biology