CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2
C. Qiu, C. Xiao, Z. Wang, G. Zhu, X. Chen, L. Gao, J. Den, J. Su, H. Su, E. F. Fang, Z. Zhang, J. Zhang, O. J. Luo, P. Wang, G. Chen
The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.
bioRxiv · Jan 22, 2021 · PreprintImmunology