C. Xiao

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

This study shows that AARS2 protects cardiomyocytes from ischemia by modulating PKM2-mediated metabolism, improving cardiac function after myocardial infarction.

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 Diabetes Mellitus Rats

This study shows that Grifola frondosa polysaccharide reduces inflammation and insulin resistance in T2DM rats by modulating liver macrophage polarization.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

A hemagglutinin and neuraminidase biased immunological memory shapes the dynamics of antibody responses to Influenza A virus

The paper shows that pre-existing immunity to specific influenza antigens biases post-infection antibody responses, altering their dynamics and breadth.

The roles of DDR2 and substrate stiffness on cancer cell transcriptome and proliferation

This study investigates how DDR2 and substrate stiffness affect cancer cell proliferation and transcriptome, revealing distinct regulatory mechanisms.

Multiscale Model for Ion Transport in Cellular Media and Applications in Smooth Muscle Cells

This paper develops a multiscale model for ion transport in multicellular tissues and applies it to study smooth muscle cell activation under various stimuli, showing the importance of gap junctions and extracellular potassium.

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic pathways, Inflammation, and Atherosclerosis

This study shows that increased hepatic Activin A expression reduces atherosclerosis by lowering cholesterol, inflammation, and fat accumulation in LDLR-/- mice on a Western diet.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

The edible seaweed Laminaria japonica contains cholesterol analogues that inhibit Lipid Peroxidation and Cyclooxygenase Enzymes

This paper isolates and characterizes five sterols from Laminaria japonica and evaluates their anti-inflammatory and antioxidant activities through enzyme inhibition and molecular docking.

Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples

Glycerol monolaurate ameliorated intestinal barrier and immunity in broilers by regulating intestinal inflammation, antioxidant balance, and intestinal microbiota

This study shows that Glycerol monolaurate improves intestinal barrier and immunity in broilers by reducing inflammation, enhancing antioxidant balance, and modulating gut microbiota.

Coordinated changes in glycosylation regulate the germinal centre through CD22

This study shows that glycan remodeling and CD22 downregulation are essential for proper germinal center function, including plasma cell output and antibody affinity maturation.

Locomotor performance and CNS responses to hypoxia in a cyclic nucleotide-gated channel mutant of adult Drosophila

This study investigates the role of CNGL channels and cGMP signaling in hypoxia response in adult Drosophila, finding impaired recovery and altered CNS K+ dynamics in CNGL mutants.

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

Genome-wide identification and transcriptional analyses of the R2R3-MYB gene family in wheat

The paper identifies 997 MYB genes in wheat, focusing on 445 R2R3-MYBs, and analyzes their expression patterns across 61 tissues and time points, revealing subgroup conservation and duplication mechanisms.

Antimicrobial emulsifier - glycerol monolaurate impacts gut micobiome inducing distinct effects on metabolic syndrome in low-fat diet fed mice

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within mosquito

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection

The paper identifies recombination and purifying selection in coronaviruses from different hosts as key factors in SARS-CoV-2 emergence.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

Arabidopsis PPC2 is crucial for growth at low CO2 by involvement in photorespiratory metabolism and integration of ABI5

This study shows that Arabidopsis PPC2 is essential for growth at low CO2 by linking photorespiratory metabolism with primary metabolism and ABA signaling.

Probiotic strains improve high-fat diet-induced hypercholesterolemia through modulating gut microbiota in ways different from atorvastatin

This study compares the hypocholesterolemia effects of four probiotic strains with atorvastatin in a high-fat diet model, showing probiotics are less effective but alter gut microbiota differently.

Loss of SHMT2 mediates 5-FU chemoresistance by inducing autophagy in colorectal cancer

This study shows that loss of SHMT2 promotes 5-FU resistance in CRC by inducing autophagy through p53 regulation.

APOC2 accelerates colorectal cancer progression via modulating lipid metabolism and transcriptional activity of PHF8

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.

Red blood cell-derived extracellular vesicles mediate intercellular communication in ischemic heart failure

The paper uses a transgenic mouse model to show RBC-derived extracellular vesicles target cardiomyocytes and microglia in ischemic heart failure, with targeted cells showing gene enrichment in proliferation and metabolism.

PD-L1:CD80 Heterodimer Triggers CD28 While Repressing Both PD-1 and CTLA4 Pathways

The paper identifies a molecular crosstalk where PD-L1 and CD80 form a heterodimer, blocking inhibitory pathways but preserving CD28 activation, and shows how PD-L1 blockade affects CD80 expression.

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.

Persistent one-way walking in a circular arena in Drosophila melanogaster Canton-S strain

This study shows that wild-type Drosophila melanogaster exhibit persistent one-way walking in a circular arena, while white-eyed mutants show frequent directional changes, with the w+ locus promoting persistent one-way walking.

AMP-activated protein kinase protects against anoxia in Drosophila melanogaster

This study shows that AMPK activation enhances anoxia tolerance in Drosophila by improving locomotor recovery and reducing ionic disruption in the brain.