Author

J. Do

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. S. Kim· 5 shared M. Sanyal· 4 shared N. Friedland· 3 shared C. Hanson· 2 shared D. B. Volkin· 2 shared M. K. Morris· 2 shared P. A.- B. Weidenbacher· 2 shared S. B. Joshi· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersImmunology

P. S. Kim

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Engineering a SARS-CoV-2 vaccine targeting the RBD cryptic-face via immunofocusing

T. U. J. Bruun, J. Do, P. A.- B. Weidenbacher, P. S. Kim

This study uses the PMD immunofocusing technique to create RBD immunogens that induce broadly neutralizing antibodies against the conserved cryptic face of SARS-CoV-2.

bioRxiv · Jun 5, 2024 · PreprintImmunology

Design of universal Ebola virus vaccine candidates via immunofocusing

D. Xu, A. E. Powell, A. Utz, M. Sanyal, J. Do, J. J. Patten, J. I. Moliva, N. J. Sullivan, R. A. Davey, P. S. Kim

This paper designs universal Ebola virus vaccine candidates using hyperglycosylation to focus antibody responses on conserved epitopes, showing cross-neutralizing activity against multiple orthoebolavirus species.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Decreased efficacy of a COVID-19 vaccine due to mutations present in early SARS-CoV-2 variants of concern

P. A. Weidenbacher, N. Friedland, M. Sanyal, M. K. Morris, J. Do, C. Hanson, P. S. Kim

This study evaluates the efficacy of a pan-sarbecovirus vaccine candidate against SARS-CoV-2 variants, finding that omitting strain-specific mutations improves cross-reactive neutralizing antibody responses.

bioRxiv · Jun 27, 2023 · PreprintBiochemistry

Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines

O. Kumru, M. Sanyal, N. Friedland, J. Hickey, R. Joshi, P. Weidenbacher, J. Do, Y.-C. Cheng, P. S. Kim, S. B. Joshi, D. B. Volkin

This study develops and compares an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced in two cell lines, showing similar immunogenicity despite differences in glycoforms.

bioRxiv · Apr 3, 2023Immunology

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

P. A.- B. Weidenbacher, M. Sanyal, N. Friedland, S. Tang, P. S Arunachalam, M. Hu, O. S. Kumru, M. K. Morris, J. Fontenot, L. Shirreff, J. Do, Y.-C. Cheng, G. Vasudevan, M. B. Feinberg, F. J. Villinger, , P. S. Kim

This paper describes a ferritin-based nanoparticle vaccine, DCFHP-alum, that induces strong, long-lasting neutralizing antibodies against SARS-CoV-2 variants in non-human primates.

bioRxiv · Dec 25, 2022Immunology

lncRNA H19/Let7b/EZH2 axis regulates somatic cell senescence

M. Potnis, J. Do, O. El Naggar, E. Noguchi, C. Sell

This study identifies the lncRNA H19/Let7b/EZH2 axis as a regulator of somatic cell senescence, showing H19 depletion leads to premature senescence and its role in modulating EZH2 levels.

bioRxiv · Jul 7, 2022 · PreprintCell Biology

Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage

S. Ciudad, E. Puig, T. Botzanowski, M. Meigooni, A. S. Arango, J. Do, M. Mayzel, M. Bayoumi, S. Chaignepain, G. Maglia, S. Cianferani, V. Orekhov, E. Tajkhorshid, B. Bardiaux, N. Carulla

This paper determines the structures of Aβ(1-42) tetramers and octamers in membrane-mimicking environments and identifies a new mechanism of membrane disruption via hydrophilic edge pores.

bioRxiv · Sep 12, 2019Biophysics