Author

J. J. Patten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

R. A. Davey· 2 shared A. Bhutkar· 1 shared A. E. Powell· 1 shared A. Jin· 1 shared A. M. Cruz· 1 shared A. M. Jaeger· 1 shared A. Radhakrishnan· 1 shared A. Singh· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

R. A. Davey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

R. J. Carlson, J. J. Patten, G. Stefanakis, B. Y. Soong, A. Radhakrishnan, A. Singh, N. Thakur, G. K. Amarasinghe, N. Hacohen, C. F. Basler, D. Leung, C. Uhler, R. A. Davey, P. C. Blainey

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

bioRxiv · Apr 6, 2024 · PreprintMicrobiology

Design of universal Ebola virus vaccine candidates via immunofocusing

D. Xu, A. E. Powell, A. Utz, M. Sanyal, J. Do, J. J. Patten, J. I. Moliva, N. J. Sullivan, R. A. Davey, P. S. Kim

This paper designs universal Ebola virus vaccine candidates using hyperglycosylation to focus antibody responses on conserved epitopes, showing cross-neutralizing activity against multiple orthoebolavirus species.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

P. M. K. Westcott, F. Muyas, O. Smith, H. Hauck, N. J. Sacks, Z. A. Ely, A. M. Jaeger, W. M. Rideout, A. Bhutkar, D. Zhang, M. C. Beytagh, D. A. Canner, R. T. Bronson, S. Naranjo, A. Jin, , T. Jacks

This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology