Author

J. Doench

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Deik· 1 shared A. R. Pacheco· 1 shared B. K. Wagner· 1 shared B. M. Davis· 1 shared B. Sit· 1 shared C. B. Clish· 1 shared C. J. Blondel· 1 shared E. S. Leshchiner· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. A. Deik

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma

Y. Zou, M. J. Palte, A. A. Deik, H. Li, J. K. Eaton, W. Wang, Y.-Y. Tseng, R. Deasy, M. Alimova, V. Dancik, E. S. Leshchiner, V. S. Viswanathan, S. Signoretti, T. K. Choueiri, J. S. Boehm, , S. L. Schreiber

This paper identifies a vulnerability in clear-cell renal cell carcinoma cells to ferroptosis induced by GPX4 inhibition, driven by the HIF-2-HILPDA pathway and PUFA-lipid enrichment.

bioRxiv · Aug 9, 2018 · PreprintCancer Biology

CRISPR screen reveals that EHEC’s T3SS and Shiga toxin rely on shared host factors for infection

A. R. Pacheco, J. E. Lazarus, B. Sit, S. Schmieder, W. Lencer, C. J. Blondel, J. Doench, B. M. Davis, M. K. Waldor

The paper uses a CRISPR screen to identify host factors critical for EHEC infection, finding shared dependencies between T3SS and Shiga toxin.

bioRxiv · May 8, 2018Microbiology