Author

S. Signoretti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. Denize· 3 shared T. K. Choueiri· 3 shared W. G. Kaelin· 3 shared C. Labaki· 2 shared D. A. Braun· 2 shared E. M. Van Allen· 2 shared E. Walton· 2 shared J. M. Asara· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

T. Denize

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The SLC1A1/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs

T. M. Grubb, J. Khatun, S. Matar, F. Ghandour, N. Dubasik, C. Salem, D. A. Orlando, M. G. Guenther, S. R. Martinez, P. Koochaki, J. A. Coker, C. Tang, E. Reznik, R. R. Kotecha, A. A. Hakimi, , A. A. Chakraborty

This study identifies SLC1A1/EAAT3 as an oncogenic transporter in ccRCC driven by H3K27ac, showing its role in sustaining metabolic programs and its potential as a therapeutic target.

bioRxiv · Sep 4, 2023 · PreprintCancer Biology

Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

J. Nyman, T. Denize, Z. Bakouny, C. Labaki, B. M. Titchen, K. Bi, S. N. Hari, J. Rosenthal, N. Mehta, B. Jiang, B. Sharma, K. Felt, R. Umeton, D. A. Braun, S. Rodig, , E. M. Van Allen

The paper uses spatially aware deep learning to identify tumor heterogeneity patterns in kidney cancer, revealing distinct states associated with different histological subtypes.

bioRxiv · Jan 18, 2023Cancer Biology

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

D. D. Shi, M. R. Savani, M. M. Levitt, A. C. Wang, J. E. Endress, C. E. Bird, J. Buehler, S. A. Stopka, M. S. Regan, Y.-F. Lin, W. Gao, J. Khanal, M. Xu, B. Huang, R. B. Jennings, , McBray

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

bioRxiv · Nov 30, 2021Cancer Biology

Regulation of Neuroendocrine Plasticity by the RNA-Binding Protein ZFP36L1

H.-Y. Chen, Y. T. Durmaz, Y. Li, A. H. Sabet, A. Vajdi, T. Denize, E. Walton, J. G. Doench, N. R. Mahadevan, J. A. Losman, D. A. Barbie, M. Y. Tolstorukov, C. M. Rudin, T. Sen, S. Signoretti, M. Oser

This study identifies ZFP36L1 as an LSD1 target gene that regulates neuroendocrine plasticity in SCLC by destabilizing mRNAs of lineage transcription factors.

bioRxiv · Oct 22, 2021Cancer Biology

Integrative Clinical and Molecular Characterization of Translocation Renal Cell Carcinoma

Z. Bakouny, A. Sadagopan, P. Ravi, N. Y. Metaferia, J. Li, S. AbuHammad, S. Tang, T. Denize, E. R. Garner, X. Gao, D. A. Braun, L. Hirsch, J. A. Steinharter, G. Bouchard, E. Walton, , S. R. Viswanathan

This study characterizes translocation renal cell carcinoma (tRCC) through integrated clinical and molecular analysis of 152 patients, identifying key features like MiT/TFE fusions, NRF2-driven antioxidant response, and differential treatment outcomes.

bioRxiv · Apr 14, 2021Cancer Biology

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

A. Chakraborty, T. Laukka, M. Myllykoski, A. Ringel, M. Booker, M. Tolstorukov, Y. Meng, S. Meier, R. Jennings, A. Creech, Z. Herbert, J. Spinelli, S. McBrayer, B. Olenchock, J. Jaffe, , W. G. Kaelin

The paper shows that KDM6A, an H3K27 histone demethylase, is oxygen-sensitive and its inactivation under hypoxia affects chromatin and cell fate.

bioRxiv · Jan 3, 2019 · PreprintBiochemistry