B. Sit

A conserved interaction between the effector Sca4 and host endocytic machinery suggests additional roles for Sca4 during rickettsial infection

Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

Candidate undecaprenyl phosphate translocases enable conditional microbial fitness and pathogenesis

The paper identifies DUF368-containing proteins as undecaprenyl phosphate translocases essential for bacterial alkaline fitness and pathogenesis in Vibrio cholerae and Staphylococcus aureus.

Proteomic interrogation of the pathogen-host interface in cholera

The paper investigates the proteomic composition of the pathogen-host interface in cholera using a rabbit model and identifies SP-D as a novel intestinal defense factor.

Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching and cofilin dependent podosome formation

This study shows that matrix stiffness and blood pressure together drive vascular smooth muscle cell phenotypic switching and cofilin-dependent podosome formation in atherosclerosis.

Genetic dissection of the fermentative and respiratory contributions supporting Vibrio cholerae hypoxic growth

This study identifies genetic factors enabling Vibrio cholerae to grow under hypoxia by combining fermentation and NO3- respiration, revealing interactions between these pathways.

Muc2 mucin limits Listeria monocytogenes dissemination and modulates its population dynamics

This study shows that Muc2 mucin restricts Listeria monocytogenes spread from the intestine and affects its population dynamics during infection.

Dissecting serotype-specific contributions to live oral cholera vaccine efficacy

This study evaluates the immunogenicity and protective efficacy of different serotype variants of a live oral cholera vaccine in a germ-free mouse model, finding minimal impact of O1 serotype variation on vaccine function.

Transient intestinal colonization by a live-attenuated oral cholera vaccine induces protective immune responses in streptomycin-treated mice

This study shows that transient intestinal colonization by a live-attenuated cholera vaccine in antibiotic-treated mice induces stronger immune protection than inactivated vaccine.

A temperature-dependent translational switch controls biofilm development in Vibrio cholerae

This study identifies a temperature-dependent translational switch mediated by BipA that controls biofilm development in Vibrio cholerae.

Actinobacillus utilizes a binding-protein dependent ABC transporter to acquire Vitamin B6

The paper identifies a Vitamin B6 uptake system in Actinobacillus using a binding-protein dependent ABC transporter, validated through structural and biochemical methods.

Functional remodeling of lysosomes by type I interferon modifies host defense

This study identifies how type I interferon remodels lysosomes to enhance Salmonella virulence and pathogenesis in intestinal epithelial cells.

Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice

This study shows that the live-attenuated cholera vaccine HaitiV provides protection against V. cholerae in mice and their offspring through immunological mechanisms, not vaccine transmission.

CRISPR screen reveals that EHEC’s T3SS and Shiga toxin rely on shared host factors for infection

The paper uses a CRISPR screen to identify host factors critical for EHEC infection, finding shared dependencies between T3SS and Shiga toxin.