M. K. Waldor

This study identifies tissue-specific bottlenecks in innate immune responses that scale with pathogen dose during E. coli infection.

This study identifies host genetic and immune factors that determine susceptibility to E. coli liver abscesses in mice using spatial and single-cell transcriptomics.

This study maps bile metabolites in mice, showing how infections alter bile composition and affect intestinal homeostasis and defense.

The paper identifies a tRNA modification in Mycobacterium tuberculosis that supports its intracellular growth by showing that its absence reduces bacterial growth in macrophages.

The paper develops Cu-tRNAseq to study peptidyl tRNA turnover in Mtb, finding Pth is essential for prolyl-tRNA recycling and identifies Pth as a potential TB therapeutic target.

The paper investigates the origins of a new cholera outbreak in Haiti in 2022 using genomic and phenotypic analysis of Vibrio cholerae isolates.

This study quantifies how host bottlenecks affect the founding population of Citrobacter rodentium during infection, showing that microbiota and dose influence pathogen establishment.

The paper identifies genomically similar, highly pathogenic STEC strains with diverse O-antigens, masking their potential risk due to rare serotypes.

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

This study shows that metabolic variation in Neisseria gonorrhoeae, specifically CO2 dependence linked to a beta-carbonic anhydrase mutation, influences the likelihood of acquiring ciprofloxacin resistance.

The paper characterizes a sequential C-to-U and U-to-Ψ RNA editing process in Vibrio cholerae tRNA mediated by TrcP, revealing its role in coupling tRNA modification states to iron availability.

The paper identifies DUF368-containing proteins as undecaprenyl phosphate translocases essential for bacterial alkaline fitness and pathogenesis in Vibrio cholerae and Staphylococcus aureus.

This study develops non-toxigenic V. cholerae challenge strains to evaluate vaccine efficacy and infer protection mechanisms, showing they accurately measure colonization reduction and vibriocidal antibody responses.

This study shows that clonal expansion of rare bacterial clones drives organ-specific outcomes during systemic infection by E. coli.

This paper introduces STAMPR, a method to improve the accuracy of measuring infection bottlenecks and pathogen dissemination using barcoded bacterial data.

The paper investigates the proteomic composition of the pathogen-host interface in cholera using a rabbit model and identifies SP-D as a novel intestinal defense factor.

The paper identifies a new family of Vibrio type III secretion system effectors containing a conserved serine/threonine kinase domain, found in diverse Vibrio species and Shewanella baltica.

The paper investigates functional redundancy in the human microbiome by analyzing genomic content networks and developing a genome evolution model to explain their topological features.

This study shows that Muc2 mucin restricts Listeria monocytogenes spread from the intestine and affects its population dynamics during infection.

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

This study identifies CvpA as a regulator of the σE stress response in EHEC, linking it to bile resistance and intestinal colonization.

This study evaluates the immunogenicity and protective efficacy of different serotype variants of a live oral cholera vaccine in a germ-free mouse model, finding minimal impact of O1 serotype variation on vaccine function.

This study investigates how Shiga toxin (Stx) from EHEC infection remodels the intestinal epithelial transcriptional response, highlighting its role in modulating immune signaling and coagulation pathways.

This study shows that transient intestinal colonization by a live-attenuated cholera vaccine in antibiotic-treated mice induces stronger immune protection than inactivated vaccine.

This study identifies a temperature-dependent translational switch mediated by BipA that controls biofilm development in Vibrio cholerae.

This study identifies how type I interferon remodels lysosomes to enhance Salmonella virulence and pathogenesis in intestinal epithelial cells.

This paper establishes an oral infection model in infant rabbits to study Shigella pathogenesis, showing it replicates human disease features and depends on T3SS and IcsA.

This study identifies LdcV as a key enzyme in Vibrio cholerae that cleaves recycled murotetrapeptides, showing its role in maintaining cell wall integrity and synthesis by preventing toxic accumulation of tetrapeptide intermediates.

The paper develops a method combining tRNA sequencing and mass spectrometry to identify and characterize tRNA modifications in bacteria, discovering new modifications and editing processes.