Author

J. E. Bear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. A. Cisterna· 2 shared E. A. Vitriol· 2 shared J. B. Black· 2 shared K. Skruber· 2 shared M. T. Butler· 2 shared T.-A. Read· 2 shared A. Cherezova· 1 shared A. E. Y. T. Lefebvre· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCell Biology

B. A. Cisterna

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cytoskeletal adaptation following long-term dysregulation of actomyosin in neuronal processes

B. A. Cisterna, K. Skruber, M. L. Jane, C. I. Camesi, I. D. Nguyen, P. V. Warp, J. B. Black, M. T. Butler, J. E. Bear, T.-A. Read, E. A. Vitriol

This study shows that long-term actin cytoskeleton dysregulation leads to compensatory changes in microtubules and intermediate filaments in neuronal processes, affecting transport and mimicking neurodegenerative disease features.

bioRxiv · Aug 25, 2023Cell Biology

The actin binding protein profilin 1 is critical for mitochondria function

T.-A. Read, B. A. Cisterna, K. Skruber, S. Ahmadieh, H. L. Lindamood, J. A. Vitriol, Y. Shi, A. E. Y. T. Lefebvre, J. B. Black, M. T. Butler, J. E. Bear, A. Cherezova, D. V. Ilatovskaya, N. L. Weintraub, E. A. Vitriol

This study identifies a novel role for profilin 1 in regulating mitochondria function and reveals a potential pathogenic mechanism for ALS-linked PFN1 variants.

bioRxiv · Aug 7, 2023Cell Biology

Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly

M. A. Quintanilla, H. Patel, H. Wu, K. A. Sochacki, M. Akamatsu, J. D. Rotty, F. Korobova, J. E. Bear, J. W. Taraska, P. W. Oakes, J. R. Beach

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

bioRxiv · Apr 26, 2023Cell Biology

Viral Airway Injury Promotes Cell Engraftment in an In Vitro Model of Cystic Fibrosis Cell Therapy

R. E. Lee, T. M. Mascenik, S. C. Major, C. A. Lewis, J. E. Bear, R. J. Pickles, S. H. Randell

This study shows that viral airway injury enhances cell engraftment in an in vitro CF model by creating conditions that favor non-CF cell integration and functional CFTR recovery.

bioRxiv · Nov 14, 2022 · PreprintCell Biology