J. W. Taraska

The paper shows that multivalent lipid binding by globular particles induces membrane deformation and clathrin-independent endocytosis, with adhesion energy determining the threshold for internalization.

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

This study identifies proteins involved in regulating caveolae shape using imaging techniques, revealing that dynamin is not directly involved in caveolae curvature.

This study shows that sterols reduce the energy required for membrane bending and fission during clathrin-mediated endocytosis, and that their depletion impairs this process and affects cellular function.

The paper reveals how clathrin lattices and adhesion receptors interact to regulate growth factor signaling through coordinated crosstalk between EGFR and β5-integrin.

This study maps Rab-GTPases and their effectors at the nanoscale in exocytic dense-core vesicles using advanced imaging techniques and reveals their circumferential distribution on vesicles.

This study shows that B cells use different endocytic mechanisms depending on BCR cluster size, switching from clathrin-mediated endocytosis to large membrane invaginations with actin and FCHSD2 recruitment.

This study determines the structural framework of clathrin-mediated endocytosis, showing flat clathrin lattices spontaneously curve into coated pits without external factors.

The paper uses live-cell imaging to study protein dynamics during microvesicle exocytosis in neuroendocrine cells, revealing roles of endocytic proteins in regulating exocytosis.

The paper uses advanced imaging techniques to study membrane bending during clathrin-coat assembly and finds that bending occurs at different stages of the process, challenging existing models.

This paper develops semisynthetic pH-sensitive fluorophores that enable imaging of exocytosis and endocytosis, matching the performance of GFP-based pHluorin.