P. W. Oakes

This study shows that Th1 T cells use integrin-mediated focal adhesions to migrate through confined environments by pulling themselves forward.

This study measures myosin cluster sizes in adherent cells and finds that cluster growth depends on ROCK activity, myosin self-affinity, and F-actin architecture.

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

This study shows non-muscle myosin 2 (NM2) filaments are processive in cells, moving against actin flow in protrusions and stress fibers, with NM2A slightly faster than NM2B.

This study compares how mutations in α-catenin's M-domain and FABD affect epithelial strength and migration by analyzing cell behavior and protein interactions.

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

This paper introduces AFT, a workflow using 2D FFT to quantify fibrillar feature alignment in microscopy images, showing advantages in flexibility, parameter efficiency, and computational speed.

This study identifies how testin, a LIM domain protein, recognizes stress fiber strain and focal adhesions through distinct domains and RhoA activation.

This study shows CD103 and CD49a on TRM cells have distinct roles in adherence and motility, impacting TRM retention and host protection after influenza infection.

The paper develops a computational model to study how integrin nanoscale properties influence adhesion assembly and stability.

The paper shows that myosin 1e and 1f are required for efficient phagocytosis by regulating adhesion turnover and actin dynamics during phagocytic cup closure.

This paper shows that cell spreading on soft substrates is inhibited by reduced adhesion formation in the lamellipodium, independent of myosin II activity.

This study uses optogenetic RhoA control to show that zyxin regulates stress fiber elasticity, revealing how localized RhoA activation drives actin flow and traction forces in fibroblasts.

This study shows that formin-dependent adhesions are essential for epithelial tissue invasion, as they enable collagen deformation and stable adhesion formation during collective motility.